Blood Spotlight Lenalidomide in non-Hodgkin lymphoma: biological perspectives and therapeutic opportunities
نویسندگان
چکیده
Elegant preclinical studies showed that T-cell immune synapse dysfunction in follicular lymphoma (FL) can be “repaired” with lenalidomide. Tumor-infiltrating T cells from FL patients had significant reduction in formation of the F-actin immune synapse vs healthy donor cells. Lenalidomide reversed these abnormalities by enhancing the immune synapse, an important finding also demonstrated in chronic lymphocytic leukemia (CLL). In addition, lenalidomide has been shown to reduceT regulatory cells, activateCD8Tcells, and skew T-helper (TH) subsets with TH1 . TH2 response. 3
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Lenalidomide in non-Hodgkin lymphoma: biological perspectives and therapeutic opportunities.
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